arXiv:2606.12854v1 Announce Type: new Abstract: Large Language Models such as GPT-4o and GPT-5 achieve strong zero-shot performance on biomedical claim verification, but cost and opacity limit scalable use. We fine-tune three small LLMs: Phi-3-mini (3.8B), Qwen2.5-3B, and Mistral-7B, via QLoRA on SciFact and HealthVer, providing the first study of QLoRA models against GPT-4o and fine-tuned BioLinkBERT encoders. Mistral-7B QLoRA surpasses both GPT-4o and GPT-5 (up to 12% F1 gain) at a fractional cost using just 1,008 training examples. We conduct extensive in-domain and cross-domain evaluation: models trained on SciFact tested on HealthVer and vice versa, at matched sizes to isolate dataset structure from data quantity. We identify a previously unreported structural artifact in SciFact that inflates in-domain scores, and show through bidirectional out-of-domain evaluation that training on structurally sound data enables robust cross-domain transfer. We plan to release all code and adapter checkpoints.
Small LLMs for Biomedical Claim Verification: Cost-Effective Fine-Tuning, Structural Dataset Shortcuts, and Cross-Domain Generalization
Researchers fine-tuned three small language models—Phi-3-mini, Qwen2.5-3B, and Mistral-7B—using QLoRA on biomedical claim verification datasets, finding that Mistral-7B outperformed GPT-4o and GPT-5 by up to 12% F1 at a fraction of the cost with only 1,008 training examples. The study identified a previously unreported structural artifact in the SciFact dataset that inflated in-domain scores, and demonstrated that training on structurally sound data enabled robust cross-domain generalization. The findings suggest that cost-effective fine-tuning of small models can match or exceed large proprietary systems for biomedical claim verification, with all code and adapter checkpoints to be released.
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