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[ARTICLE · art-21138] src=arxiv.org pub= topic=large-language-models verified=true sentiment=· neutral

Can I Take Another Dose? Evaluating LLM Decision-Making Under Temporal Uncertainty in OTC Dosing QA

Researchers introduced DOSEBENCH, a benchmark of 81 over-the-counter dosing scenarios for adult acetaminophen and ibuprofen, to evaluate large language models' ability to answer safe dosing questions. Testing four models across 1,620 responses revealed frequent failures in rolling-window reasoning and handling ambiguous cases, with confident-sounding answers sometimes violating dosing constraints. The findings highlight that OTC dosing QA offers a practical testbed for assessing temporal reasoning and safety-relevant uncertainty in medical AI applications.

read1 min publishedJun 4, 2026

arXiv:2606.04262v1 Announce Type: new Abstract: Large language models (LLMs) are increasingly used for everyday health questions, including whether a user can safely take another dose of an over-the-counter (OTC) medication. Yet this common safety-relevant setting remains underexplored in existing medical QA evaluations, where correct answers require tracking dose timing, computing rolling 24-hour intake, following product-label constraints, and handling incomplete medication histories. We introduce DOSEBENCH, a focused benchmark of 81 curated OTC dosing scenarios focused on adult acetaminophen and ibuprofen use, with manually annotated gold references. We evaluate four LLMs across repeated runs using metrics for decision correctness, consistency, explanation verifiability, failure types, and confidence-related signals, resulting in 1,620 model responses. Our results show that models frequently struggle with rolling-window reasoning and ambiguity-sensitive cases and that stable or confident-looking responses can still violate dosing constraints. These findings suggest that OTC dosing QA provides a narrow yet practical testbed for evaluating temporal reasoning, constraint following, and safety-relevant uncertainty handling in medical QA.

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