04:00
2026-08-20
machinebrief.com
artificial-intelligence
Training Chemical Plausibility-Aware Large Language Models for Single-Step Retrosynthesis
Researchers introduced Top-K prompting and the C3LM (Chemistry Constraint-Consistent Language Model), trained on the CREED-CCV-2+USPTO-XL dataset of ~45.6 million verified reactions, achieving state-o…