Why aren't we using LLM's to chemically redesign old drugs?

A Hacker News user proposed using large language models to chemically redesign old drugs, specifically suggesting a Pt(IV) prodrug version of cisplatin with albumin-binding and glutathione-synthesis inhibitor ligands to reduce toxicity and improve tumor targeting. The post, which received 1 point and no comments, explores whether LLMs like ChatGPT could aid in drug redesign.

I was fooling around with Cisplatin, a chemo drug that made testicular cancer curable. Then I was like, I wonder how Chat GPT would improve this drug. It tried. Is this a good idea? "The best chemical improvement is unlikely to be “a stronger cisplatin.” It should be a less reactive circulating molecule that becomes ordinary cisplatin only after tumor uptake. My preferred candidate is therefore: A neutral, asymmetric cisplatin-based Pt IV prodrug with one stabilized albumin-binding axial ligand and one reduction-released glutathione-synthesis inhibitor, with the axial electronics deliberately tuned to prevent premature blood reduction." Comments URL: https://news.ycombinator.com/item?id=49074935 https://news.ycombinator.com/item?id=49074935 Points: 1 Comments: 0