# Why aren't we using LLM's to chemically redesign old drugs?

> Source: <https://news.ycombinator.com/item?id=49074935>
> Published: 2026-07-27 20:10:45+00:00

I was fooling around with Cisplatin, a chemo drug that made testicular cancer curable. Then I was like, I wonder how Chat GPT would improve this drug. It tried. Is this a good idea?

"The best chemical improvement is unlikely to be “a stronger cisplatin.” It should be a less reactive circulating molecule that becomes ordinary cisplatin only after tumor uptake. My preferred candidate is therefore: A neutral, asymmetric cisplatin-based Pt(IV) prodrug with one stabilized albumin-binding axial ligand and one reduction-released glutathione-synthesis inhibitor, with the axial electronics deliberately tuned to prevent premature blood reduction."

Comments URL: [https://news.ycombinator.com/item?id=49074935](https://news.ycombinator.com/item?id=49074935)

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