Static Recovery Is Not Dynamic Stability: Dynamics-Aware Benchmarking of Protein Motif Scaffolding

A new benchmarking approach argues that protein motif scaffolding evaluations are limited by small hand-curated motif sets and static refolding criteria, and proposes dynamics-aware assessment of scaffold stability instead. The work, titled "Static Recovery Is Not Dynamic Stability: Dynamics-Aware Benchmarking of Protein Motif Scaffolding," contends that benchmark conclusions depend on which motifs are tested and which criteria define success. The paper's abstract does not report specific quantitative results.

Protein motif scaffolding benchmarks assess whether generative models can build scaffolds around functionally important residues. Their conclusions depend on which motifs are tested and which criteria define success. Existing benchmarks typically use small hand-curated motif sets and static refoldin