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[ARTICLE · art-132636] src=nature.com ↗ pub= topic=ai-agents verified=true sentiment=↑ positive

Stanford's Paper2Agent, now in Nature: turn a research paper into an MCP server other agents can call

Stanford researchers Jiacheng Miao and James Zou published Paper2Agent in Nature on September 16, a system that converts a research paper's methods, code and data into an MCP server other agents can call. On 100 biomedical papers, 74 converted and 593 of 599 proposed tools passed validation, while on 300 questions it scored 91.2 percent at about $0.20 a query; for AlphaGenome it built 22 tools in roughly 45 minutes for $14, all passing. The MIT-licensed code is at github.com/jmiao24/Paper2Agent, though 26 of the 100 papers failed to convert.

read1 min views4 publishedSep 17, 2026

Published September 16, led by Jiacheng Miao and James Zou. The idea: a paper's methods, code and data become tools an agent can run, instead of a PDF it reads. Each paper becomes three things: executable tools that wrap its methods, resources holding the manuscript and datasets, and prompts that encode the workflow. Every tool is tested before it ships. Numbers from the paper as reported by MarkTechPost: for AlphaGenome it built 22 tools in about 45 minutes for $14, all passing. On a set of 100 biomedical papers, 74 converted and 593 of 599 proposed tools passed validation. On 300 questions it scored 91.2 percent at about $0.20 a query. Code is MIT-licensed at github.com/jmiao24/Paper2Agent. Why it matters: the same trick works on any internal runbook or script library you own. What to watch: 26 of 100 papers failed to convert, so it is not magic.

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