Spinal neuromotor rehabilitation using a portable isokinetic training robot

Abstract Most lower-extremity assistive robots are designed to actively assist gait1-7 without considering long-term neuromuscular adaptations8-11. In this study, we present a lightweight (0.96 kg) robot that administers isokinetic resistance training to sustain neuromuscular rehabilitation after removal. The device integrates a variable stiffness mechanism with a back-drivable damping motor to make available safe, portable, and customizable resistance training to juveniles with Spinal Muscular Atrophy (SMA) type II. In a study involving 6 such juvenile participants, significant improvements in lower-extremity motor ability were observed after 6 weeks of robot-assisted training in a clinical trial (NCT06648486). Participants gained the ability to perform sit-to-stand transitions with hands on knees but without external support from an average seated knee flexion angle of 111° to 104°, representing a 7° improvement from pre-intervention. This improvement was accompanied by significantly increased bilateral knee joint function (peak torque: +130%; range of motion: +51%; work: +97%). Significant physiological quadriceps muscle hypertrophy was observed (anatomical cross-sectional area: +12%; volume: +19%; physiological cross-sectional area: +21%) alongside enhanced femoral nerve conduction (compound muscle action potential: +19%), representing physiological changes consistent with the observed functional improvements. Importantly, participants were able to retain their gains after discontinuing isokinetic training and returning to their conventional physiotherapy routines. These results suggest that even temporary exposure to isokinetic resistance training through wearable robotics may facilitate enduring neuromuscular recovery. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27,99 € / 30 days cancel any time Subscribe to this journal Receive 51 print issues and online access 199,00 € per year only 3,90 € per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Author information Authors and Affiliations Corresponding author Supplementary information Supplementary Information (download PDF ) This file contains Supplementary Methods 1-17, Supplementary Notes 1-16, Supplementary Figures 1-38, Supplementary Tables 1-31 and Supplementary References. Supplementary Video 1 (download MP4 ) Robot design and structure. Rights and permissions About this article Cite this article Li, Y., Ren, J., Shu, T. et al. Spinal neuromotor rehabilitation using a portable isokinetic training robot. Nature (2026). https://doi.org/10.1038/s41586-026-10642-0 Received: Accepted: Published: DOI: https://doi.org/10.1038/s41586-026-10642-0