Show HN: Pantheon. Production-ready scientific workflows for the Horus Runtime

Temple Compute released Pantheon, a collection of production-ready scientific workflows for its Horus Runtime, covering molecular dynamics, virtual screening, docking, and LLM training. The workflows are multi-stage pipelines that automatically route each stage to the appropriate compute cluster type (HPC, cloud, or local), eliminating the need for custom glue code. Pantheon is available on GitHub and includes documentation, workflow definitions, and scripts for each pipeline.

You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert Production-ready scientific workflows for the Horus Runtime. Molecular dynamics, virtual screening, docking, LLM training, and more. Each workflow is a multi-stage pipeline that routes every stage to the right cluster type automatically: HPC, cloud, or local. Why Pantheon? Stop writing glue code. Declare your pipeline once and Horus runs it across heterogeneous compute, streams logs live, retries failures, and produces typed artifacts you can trace. Star the repo ⭐ if you build scientific pipelines, it helps more people find these workflows. Each workflow directory contains: README.md: purpose, pipeline, install steps, and configuration guide workflow.yaml or run.py: a plain Horus workflow definition or Python workflow builder scripts/: small stage scripts and helper code when needed Getting Started 1. Install uv recommended curl -LsSf https://astral.sh/uv/install.sh | sh 2. Clone this repo git clone https://github.com/temple-compute/pantheon cd pantheon 3. Install horus-runtime from inside any workflow directory cd workflows/drug-discovery/w01-boltz2-virtual-screening uv sync or, if you prefer pip: pip install horus-runtime horus-environments 4. Run the workflow uv run horus run workflow.yaml BioExcel workflows also require a conda-family tool micromamba, mamba, or conda on your PATH. Their executors build conda environments to provision GROMACS, AMBER, and related simulation tools. More on executors at docs.templecompute.com. One measurable task per execution mechanism subprocess, venv, container, in-process as an acceptance harness for per-task resource measurement Contributing See CONTRIBUTING.md for how to add new workflows or improve existing ones. About Production-ready scientific workflows for the Horus Runtime: molecular dynamics, virtual screening, docking, LLM training and more. HPC pipelines that actually run at scale.