# Show HN: Pantheon. Production-ready scientific workflows for the Horus Runtime

> Source: <https://github.com/temple-compute/pantheon>
> Published: 2026-08-12 06:13:10+00:00

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Production-ready scientific workflows for the Horus Runtime. Molecular dynamics, virtual screening, docking, LLM training, and more. Each workflow is a multi-stage pipeline that routes every stage to the right cluster type automatically: HPC, cloud, or local.

Why Pantheon? Stop writing glue code. Declare your pipeline once and Horus runs it across heterogeneous compute, streams logs live, retries failures, and produces typed artifacts you can trace.

Star the repo ⭐ if you build scientific pipelines, it helps more people find these workflows.

Each workflow directory contains:

README.md: purpose, pipeline, install steps, and configuration guide

workflow.yaml or run.py: a plain Horus workflow definition or Python workflow builder

scripts/: small stage scripts and helper code when needed

Getting Started

```
# 1. Install uv (recommended)
curl -LsSf https://astral.sh/uv/install.sh | sh

# 2. Clone this repo
git clone https://github.com/temple-compute/pantheon
cd pantheon

# 3. Install horus-runtime from inside any workflow directory
cd workflows/drug-discovery/w01-boltz2-virtual-screening
uv sync
# or, if you prefer pip:
# pip install horus-runtime horus-environments

# 4. Run the workflow
uv run horus run workflow.yaml
```

BioExcel workflows also require a conda-family tool (micromamba, mamba, or conda) on your PATH. Their executors build conda environments to provision GROMACS, AMBER, and related simulation tools. More on executors at docs.templecompute.com.

One measurable task per execution mechanism (subprocess, venv, container, in-process) as an acceptance harness for per-task resource measurement

Contributing

See CONTRIBUTING.md for how to add new workflows or improve existing ones.

About

Production-ready scientific workflows for the Horus Runtime: molecular dynamics, virtual screening, docking, LLM training and more. HPC pipelines that actually run at scale.