LLM-Guided ANN Index Optimization for Human-Object Interaction Retrieval Researchers developed a phase-aware large language model agent that optimizes retrieval system parameters by conditioning each proposal on its full optimization history, overcoming the limitations of traditional hyperparameter methods that assume parameter independence. Tested on the HICO-DET human-object interaction retrieval benchmark, the LLM agent outperformed Optuna TPE by 33.3% and VDTuner by 34.2% in quality-constrained throughput, delivering a 15.3x throughput gain over UniIR. The agent's advantage increased with parameter coupling strength, and cross-system validation on Milvus confirmed its transferability across vector database management platforms. arXiv:2606.05489v1 Announce Type: new Abstract: Retrieval systems underpin modern AI applications -- spanning visual search, recommendation engines, and multi-modal question answering. Modern multi-stage retrieval systems require the joint optimization of highly coupled parameters, yet traditional hyperparameter optimization HPO methods -- including Tree-structured Parzen Estimators TPE and Gaussian Process Bayesian Optimization -- rely on an independence assumption that fundamentally prevents them from navigating these coupled configuration spaces. We address this limitation with a phase-aware large language model LLM agent that conditions each proposal on its full optimization history, navigating the coupled parameter space across phase-partitioned exploration, exploitation, and fine-tuning stages. Evaluated on the HICO-DET human-object interaction retrieval benchmark using Intel VDMS Visual Data Management System , our agent outperforms Optuna TPE by +33.3% and VDTuner by +34.2% under SIEVE Safeguarded Index Evaluation of Vector-search Efficiency, a quality-constrained throughput metric , delivering a 15.3x throughput gain over UniIR. Validation across three benchmarks confirms that the agent's advantage grows with the degree of parameter coupling: +33.3% on HICO-DET high coupling , methods converge within 1% on GLDv2 moderate coupling and within 3.6% on SIFT1M near-independent control . Cross-system validation on Milvus confirms the optimizer ranks first on all three datasets without modification, demonstrating transferability across vector database management system VDBMS platforms.