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[ARTICLE · art-92512] src=ycombinator.com ↗ pub= topic=artificial-intelligence verified=true sentiment=↑ positive

Gamgee

Gamgee, a startup founded by machine learning expert Paul, is using AI to develop the first computationally personalized mRNA cancer vaccine for dogs, after his own dog Rosie's tumors shrank 50-75% with a vaccine he designed. The company aims to reduce vaccine design time from a year to 48 hours and cost from $20,000 to $2,000, targeting the six million dogs diagnosed with cancer annually in the U.S. Gamgee is now planning a clinician-led trial in 30 dogs.

read2 min views1 publishedAug 11, 2026

We believe that AI meets biology is the biggest opportunity of the 21st century. We are using AI to build autonomous systems that read biological failure, discover how to control it, and design precise repairs. We are starting with the first computationally personalised mRNA cancer vaccine for dogs.

My dog Rosie was dying of cancer. I designed her an mRNA vaccine. Several of her tumours shrank 50-75%. I am not a biologist - I spent 17 years in machine learning. Doing it by hand took a year and around $20,000. Gamgee is turning that process into software. Our target is a vaccine design in 48 hours and an end-to-end cost of $2,000

https://www.youtube.com/watch?v=-Jb41jTc0U0 How it works

The market

Approximately six million dogs are diagnosed with cancer every year in the United States, and cancer is the leading cause of death in adult dogs. Owners who pursue specialist treatment spend thousands on surgery, chemotherapy and radiation.

The compounding data advantage

Every dog we treat returns sequencing, immune and outcome data for a species where datasets remain scarce. That data improves target selection, which improves the next vaccine, which produces better data. We are not just early to the problem - we are the ones accumulating the data that solves it.

Proof so far

Rosie was one patient. Our next step, already well underway, is a clinician-led trial in 30 dogs to evaluate safety, immune response and clinical outcomes.

Why dogs first, and not only dogs

Most modern dog breeds were created within the last few hundred years from small founder populations and then bred within closed gene pools. This concentrates inherited cancer risk, leaving many breeds unusually prone to particular cancers.

Pet dogs develop cancer naturally, not in a laboratory. Their immune systems are intact and their disease progresses on timelines that let us learn quickly. Dogs are a real market in their own right and the fastest place to get good at personalised cancer vaccines.

Our ask

We are building Gamgee so that no other dog waits for hope which arrives too late.

Reach me at paul@gamgee.io or gamgee.io I love you Rosie.

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