ElevenLabs + Twilio: Building Voice Call Applications A developer has published a step-by-step guide for building an AI-powered voice call application that combines Twilio's telephony webhooks with ElevenLabs' text-to-speech API and OpenAI's GPT-4o-mini for conversational responses. The Flask-based example routes inbound calls through Twilio's speech recognition, generates a reply via ChatGPT, and plays back ElevenLabs-generated audio, with ngrok used to expose the local server to Twilio's webhook. If you’ve ever wanted to turn a simple phone call into an interactive, AI‑powered experience, you’re in the right place. Twilio gives you the plumbing to make and receive voice calls, while ElevenLabs provides state‑of‑the‑art text‑to‑speech TTS and voice cloning. Put them together and you can build everything from personalized voicemail assistants to real‑time language translation over the phone. In this post we’ll walk through a minimal but fully functional example: