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[ARTICLE · art-112341] src=forum.level1techs.com ↗ pub= topic=ai-infrastructure verified=true sentiment=· neutral

Does anyone have experience working with ROCm and CUDA on the same machine?

A user with an AMD RX 7900 XT is considering adding lower-end Nvidia RTX GPUs to run multiple local AI models on different cards, but is concerned about potential issues with running ROCm and CUDA side-by-side. The user asks whether there are material limitations beyond setup inconvenience, planning to put a mid-tier model on the 7900 and lower-tier models on the RTXs.

read1 min views1 publishedAug 26, 2026

I have a RX 7900 XT in my machine and might be able to get one or two lower end RTXs.

I have been experimenting with running models locally and thought it would be interesting to try and load multiple models on different gpus and route between them.

However, here and there I read that heterogeneous hardware can be a real headache (eg, using ROCm and CUDA side-by-side) and that it should be avoided. (I don’t actually have a link to where I read this, it has been just in passing and that was the impression I got.)

I get having all the various tools installed and needing to set things up to work with both are extra steps, but is there a material limitation or disadvantage to doing this? Something beyond annoyance or inconvenience?

I’m interested this for the sake of knowing, but for added context my current plan is to put a mid-tier model on my 7900 and then lower tier models on the RTXs.

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