Claude Fable 5.1 and Claude Mythos 5.1

Anthropic introduced Claude Fable 5.1 and Claude Mythos 5.1, the same model with different safeguard levels, claiming they are the world's most advanced models for coding and knowledge work. Fable 5.1 is generally available and priced about 25% less than Fable 5 for typical workloads, with savings up to 45% for agentic work, while Mythos 5.1 is restricted to trusted access programs for cybersecurity and life sciences. The models show significant benchmark gains, including a 52.6% score on Terminal-Bench-Science 0.1 versus Fable 5's 24.7%, and Anthropic also introduced Enterprise Frontier Safeguards for complete customer data privacy.

We’re introducing Claude Fable 5.1 and Claude Mythos 5.1. They’re the world’s most advanced models for coding and knowledge work—and their research capabilities offer an early glimpse of how AI models will contribute to scientific progress. Claude Fable 5.1 and Claude Mythos 5.1 are the same model, but with different levels of safeguards. Fable 5.1 is generally available, while Mythos 5.1 is available only through our trusted access programs; its safeguards are specifically designed to support work in cybersecurity and the life sciences. Alongside its increased capabilities, Fable 5.1 takes important steps towards addressing the feedback we’ve received from customers on price, data retention, and safeguards. Price . Fable 5.1 will cost an estimated 25% less than Fable 5 for typical workloads, wherever usage is billed by token. This is because we’re reducing our pricing on cache reads where the model reads inputs that have already been processed and stored . For highly agentic work, the savings will often be much larger—up to approximately 45%. Data retention . Our new system of Enterprise Frontier Safeguards EFS gives customers complete privacy the same as a zero data retention policy while still being state-of-the-art at preventing adversarial use. EFS works by storing data in cloud infrastructure controlled entirely by the customer, not Anthropic. It will be made available to enterprise customers in phases, beginning later this fall. Until EFS is available, eligible customers will be able to use Fable 5.1 with zero data retention. Safeguards . We’ve improved our safeguards to reduce false positives where the system flags benign content . In cybersecurity, our newest safeguards block 60% fewer false positives than before. In part, this is because Fable 5.1 can now be used to discover software vulnerabilities—though not develop exploits for them. In biology, we’ve established an access program, developed in partnership with the US government, to enable access to Claude Mythos 5.1’s advanced biology capabilities. We expect to open enrollment for scientists soon. A new performance frontier Claude Fable 5.1 sets a new standard on coding, knowledge work, and long-running problem-solving tasks. The charts below show that Fable 5.1 is capable of much higher performance than its predecessor, Fable 5. And when set to Low or Medium effort, Fable 5.1 achieves similar or better results than Fable 5 at a much lower cost. Note that Fable 5.1 defaults to High effort in Claude Code, and to Medium in Claude Cowork and on Claude.ai. Fable 5.1 avoids shortcuts that result in poorer-quality work, and it’s smart enough to fix the root causes of software issues. For example, in testing by the investment firm Millennium, Fable 5.1 found the cause of a rare crash on their internal systems that none of their engineers or any other model had been able to explain after several years of trying. Here, you can see how Fable 5.1 compares across various benchmarks: | Fable 5.1 | Fable 5 | Opus 5 | GPT-5.6 Sol | | |---|---|---|---|---| | Agentic scientific researchTerminal-Bench-Science 0.1 | 52.6% | 24.7% | 29.0% | 22.4% | | Agentic codingTerminal-Bench 4.0 | 55.8%60.9% Mythos 5.1 | 42.0% | 52.3% | 37.3% | | Knowledge workGDPval-AA v2 | 1853 | 1723 | 1824 | 1711 | | Computer useOSWorld 2.0 | 77.9%partial | 72.9%partial | 75.4%partial | —partial | | 41.7%strict | 36.1%strict | 39.6%strict | —strict | | | Multidisciplinary reasoningHumanity's Last Exam | 60.9%no tools | 57.8%no tools | 56.6%no tools | —no tools | | 65.0%with tools | 63.8%with tools | 63.6%with tools | —with tools | | | Business workflowsAutomationBench | 31.4% | 17.1% | 26.9% | 19.6% | | Agentic codingCursorBench 3.2.0 | 73.4% | 70.5% | 70.0% | 67.2% | Our early-access partners noticed these performance upgrades, and also picked up on more qualitative improvements in the model’s outputs. Here’s what they told us: 1 of 22 Scientific research We tested Claude Fable 5.1 and Claude Mythos 5.1’s scientific research capabilities across a wide range of domains. What we found—which includes the early examples we share below—adds to the evidence that AI models will soon make important contributions to scientific discovery. Molecular design . Many modern medicines work by binding to targets within the body to block, activate, or deliver something to them. High-affinity binders are necessary for drugs to work at lower doses; designing one is the first step in the development process for many common drug modalities. To see how well Claude Mythos 5.1 could do at this task, we gave the model access to open-source protein design and folding tools and sent its designs to two external organizations for experimental validation. Mythos 5.1 proved able to design very high-affinity binders. On three targets, its binding affinities were 10 times higher than the best designs submitted to Adaptyv Bio’s protein design competitions https://proteinbase.com/competitions . Its hit rate that is, the number of designs that were viable binders was the strongest we’ve measured to date: it reached nearly 50% across 12 targets. Hit rates of 10-15% are typical in protein design today. Computational analysis and modeling . Claude Fable 5.1 trained a neural network to create a new, high-resolution elevation map of a third of the planet Venus. Its work was based on radar images taken by NASA’s Magellan mission more than 30 years ago and a map https://agupubs.onlinelibrary.wiley.com/doi/full/10.1029/2012EO120002 that already existed for one-fifth of the planet. Claude’s new map now reveals details down to two to three kilometers, rather than 10 to 20, and shows heights up to 25% more accurately than before. We’re releasing this map https://zenodo.org/records/22164484 under a Creative Commons license in advance of upcoming NASA VERITAS and ESA EnVision missions, in the hope it might help them determine which geologic features to target for future observation. Computational biology . In computational biology, it’s common to run task-specific machine learning models on GPUs. The speed of these models is therefore a bottleneck to research progress. Mythos 5.1 provided one solution to this problem: by writing custom GPU kernels and caching their intermediate results, it sped up seven open-source deep learning models by up to 2.5 times with identical outputs . The benefits of such speed-ups accumulate quickly. In any given experiment, biologists might run these models thousands of times for example, testing every possible mutation near every human gene . On analyses like these, the optimized models cut estimated GPU costs by 30 to 60%. This kind of optimization would normally take a team of performance engineers weeks, and is often unaffordable for academic labs. Mythos 5.1 was able to do it in just days, using the publicly available source code alone. We plan to open-source these optimizations soon. As our models’ scientific capabilities improve, our investment in scientific progress is also growing. Last week, we previewed the Model Hardware Standard https://www.anthropic.com/news/model-hardware-standard-research-preview , which allows Claude to directly and safely operate laboratory equipment. We’ve also recently expanded our support for scientists https://www.anthropic.com/news/expanding-support-for-scientists through our AI for Science program https://www.anthropic.com/news/ai-for-science-program , which provides free credits to researchers working on high-impact scientific projects, and we are offering steeply discounted usage through our new Claude Team plan for scientists https://claude.com/programs/team-plan-for-scientists . Safety, security, and alignment AI models’ agentic capabilities have become much more powerful over the past two years. But as we’ve documented https://www.anthropic.com/news/investigating-incidents-cybersecurity-evals , greater autonomy comes with new risks. Work on safety, security, and alignment needs to advance at the same pace as AI capabilities. Yesterday, we published a report https://www.anthropic.com/news/improving-alignment-security-efforts describing how we are improving our own alignment and security efforts. Prior to releasing Claude Fable 5.1 and Claude Mythos 5.1, we and, in some cases, external researchers subjected the models to extensive testing for risks across many areas. We describe these efforts in full in our System Card https://www.anthropic.com/claude-fable-5-1-mythos-5-1-system-card ; below is a brief summary. Chemical and biological risks . We tested the extent to which Claude Mythos 5.1 could help create chemical or biological weapons. This involved expert red-teaming, automated evaluations, and a tabletop exercise that paired PhD-level biologists with AI experts, testing whether the models could match human specialists’ performance. Mythos 5.1’s capabilities are greater than those of Mythos 5. However, our evaluations indicate that it still falls short of the next risk tier defined in our Responsible Scaling Policy https://www.anthropic.com/responsible-scaling-policy . We are therefore deploying Mythos 5.1 with the same safeguards https://www.anthropic.com/news/improving-fable-5-s-biology-safeguards that we applied to Mythos 5, which restrict access to research biology capabilities. Cyber risks . We ran a suite of evaluations to assess the cyber capabilities of Claude Mythos 5.1 with cybersecurity safeguards off . Overall, the model demonstrates the strongest cyber capabilities of any model we’ve released, though it still falls within the lower category of risk in our Frontier Compliance Framework https://www.anthropic.com/news/compliance-framework-SB53 . We also performed extensive stress-testing of our cybersecurity safeguards for Fable 5.1: as well as our own dynamic evaluation of their robustness, we commissioned external testing from two organizations, along with automated testing by Gray Swan https://www.grayswan.ai/ . As with Fable 5 and Opus 5, we have not found evidence of a critical-severity jailbreak https://www.anthropic.com/news/fable-safeguards-jailbreak-framework for these safeguards. Agentic safety . We ran evaluations of how Claude Mythos 5.1 responds to malicious requests and prompt injections adversarial instructions hidden within content processed by AI models . It refused malicious agentic coding and computer use requests at a comparable rate to Mythos 5, Sonnet 5, and Opus 5, and it is our most robust model to date on an external prompt injection benchmark https://www.anthropic.com/claude-fable-5-1-mythos-5-1-system-card . Alignment . We tested the model’s behavior through static and interactive behavioral evaluations, analyses of its internal thinking using natural language autoencoders https://www.anthropic.com/research/natural-language-autoencoders , misalignment-related capability evaluations, a review of our training data, and analyses of our internal pilot use. We also received reports from external testing. Our automated behavioral audit found that Claude Mythos 5.1 is better aligned across most metrics than its predecessor, Mythos 5. The model is significantly less likely than Mythos 5 to try to access resources outside of its test environment when assigned an otherwise impossible task. It is also less likely than Mythos 5 to use motivated reasoning to justify its actions for instance, by reasoning that the situation is a simulation or evaluation , and it is less likely to ignore explicit constraints in pursuit of users’ goals. From our review of its training data, Mythos 5.1 both attempts and succeeds at reward hacking or cheating at a lower overall rate than Mythos 5. Though generally our alignment evaluations showed improvements, our testing found the model can still sometimes bypass approvals and auto-mode classifiers as we discuss in more detail in our System Card https://www.anthropic.com/claude-fable-5-1-mythos-5-1-system-card . There are also limitations to the coverage provided by our alignment assessment. Currently, our automated behavioral audit provides less visibility into very long-context work and multi-agent settings. We also have less coverage of impossible tasks which can elicit more abnormal and misaligned behavior than we’d like, although we’ve recently made improvements in this domain and are working hard to continue doing so. We have also improved our safeguards so that they allow our models to be more useful without compromising on safety. We describe these changes below. Automated safeguards for enterprises . Enterprise Frontier Safeguards https://www.anthropic.com/news/enterprise-frontier-safeguards EFS allows us to detect and respond to misuse of our models while still providing our enterprise customers the privacy of a zero data retention agreement. With EFS, customers store their data on their own cloud infrastructure, rather than on Anthropic’s systems; any human review is, by default, done by the customer themselves, rather than Anthropic. We developed EFS in close collaboration with more than 100 customers across industries like financial services, healthcare, manufacturing, telecom, law, retail, and the public sector, and with our cloud partners at Amazon Web Services, Google Cloud, and Microsoft Azure. EFS will be supported on Claude Code, Claude Enterprise, the Claude Platform, Amazon Bedrock, Claude Platform on AWS, Google’s Agent Platform, and Microsoft Foundry. It’s rolling out in phases, starting this fall. As noted above, customers who are eligible for EFS can use Fable 5.1 and Fable 5 with zero data retention until EFS is ready. You can read more about EFS here; to request access, please complete https://www.anthropic.com/news/enterprise-frontier-safeguards this form https://claude.com/form/enterprise-frontier-safeguards . More precise safeguards for biology and cybersecurity . In the past few months, we’ve made progress in making our safeguards for Fable 5.1 more precise: ensuring that they’re less likely to flag benign content like queries about medical issues or cyberdefenders using the model to make their systems safer , but still ensuring they provide robust protection against genuine threats. As we recently shared https://www.anthropic.com/news/improving-fable-5-s-biology-safeguards , our latest biology safeguards for Fable 5.1 and Fable 5 fire 85% less often for benign requests related to elementary biology and medical questions relative to those that launched with Fable 5 . However, queries related to research and development in the life sciences will still be directed to our Opus models. We’re making the model’s life sciences capabilities available to professionals through an access program for Claude Mythos 5.1 that we’ve developed in partnership with the US government, which we discuss below. With Fable 5.1, we’re updating our cybersecurity safeguards to be more precise. We’re also now allowing Fable 5.1 to be used for identifying software vulnerabilities—that is, to conduct the kind of defensive work that improves software security. As a result of these changes, Claude Code users can expect an average of around 60% fewer interventions per session from our cyber safeguards, relative to the previous safeguards on Fable 5. Our safeguards do, however, still redirect several kinds of dual-use cybersecurity tasks tasks that might have helpful or harmful applications to our Opus models. This includes penetration testing, exploit generation, and binary-based vulnerability scanning. Anti-distillation mechanisms . Distillation is a method used to extract the capabilities of advanced models. It is often employed on an industrial scale, using thousands of fake accounts. Distillation is a safety risk, since the distilled capabilities can subsequently be released without adequate safeguards. Fable 5.1 comes with strengthened mechanisms to make distillation attacks harder. For example, it is no longer possible for new API accounts those created from today onwards to manually edit Claude’s prior context in a multi-turn conversation while preserving the transcript of Claude’s prior thinking. This closes off a common, publicly documented distillation technique, which allowed distillers to illicitly extract Claude’s thinking. We’re rolling out the change gradually, to minimize disruption: existing accounts are not currently affected by this change, though it will apply to all users with future model releases. A small number of customers’ custom integrations will then be affected. Our Help Center article https://support.claude.com/en/articles/16761192 explains more about this change and the adjustments that developers can make. Trusted access for Claude Mythos 5.1 Claude Mythos 5.1 is identical to Fable 5.1, but it offers more permissive safeguards for vetted individuals and organizations whose work is affected by the cybersecurity and life sciences restrictions outlined above. It will be available through two trusted access programs: Cyber Verification Program: The CVP currently provides access to certain Opus and Sonnet-class models with reduced cyber safeguards for defensive security work. In the near future, this program will also include access to Claude Mythos-class models. To apply to join the CVP, click here https://portal.anthropic.com/programs/cvp . Life Sciences Verification Program: The LSVP is designed so that life sciences professionals can use Claude Mythos 5.1 with safeguards designed for professional research and development activities while all other safeguards remain in place . In partnership with the US government, we have enrolled our first participants, and we plan to expand access to this program to the broader life science community. In addition to these trusted access programs, Claude Security https://claude.com/product/claude-security , our product that scans codebases for vulnerabilities and suggests patches for human review, is now also powered by Claude Mythos 5.1. Compliance with the EU AI Act In July 2026, Anthropic along with 190 other signatories https://digital-strategy.ec.europa.eu/en/news/strong-backing-code-practice-transparency-ai-generated-content , including several other major AI model providers signed the EU AI Act’s Code of Practice on Transparency of AI-Generated Content. This required us to add a watermark—a numerical way of determining the likelihood that Claude was involved in writing a piece of text—to the outputs of models released after August 2, 2026. As we recently explained https://www.anthropic.com/news/claude-text-watermark , this watermark is invisible to anyone who does not have the detection API. It has no practical impact on the quality or content of Claude’s outputs and contains no information about the user, their organization, or their conversations with Claude. The Act also required us to provide a way for users to tell whether a text likely contains the watermark. We are thus rolling out a detection API in private preview. It is currently available to eligible organizations as required under EU law such as regulators, law enforcement, media, fact-checkers, independent researchers, educational organizations, and EU civil society groups . It is also available for enterprises who are similarly obligated to verify watermarking for their own compliance with the Act. We plan to expand access to the detection API over time. You can register interest in access here https://forms.gle/9tGA33hPJJwtHsMk9 . Cost and availability Claude Fable 5.1 is available today on all platforms, including Amazon Web Services, Google Cloud, and Microsoft Azure. Developers can get started with claude-fable-5-1 on the Claude API. As mentioned above, we have reduced the price of Fable 5.1’s cache reads where the model reuses context it has already processed wherever usage is billed by token, such as on our API. Cache reads now cost 75% less, or $0.25 per million tokens. This change leads to a substantial reduction in the overall cost of running the model. For typical workloads, costs are reduced by around 25% relative to Fable 5. For complex coding and highly agentic tasks, the savings could be up to around 45%. The graph below illustrates why this change makes such a big difference: Fable 5.1’s pricing is otherwise the same as Fable 5’s: $10 per million input tokens and $50 per million output tokens. In parallel, we’re continuing our work to bring many of the improvements of Fable 5.1 to the rest of our model family. As discussed above, Claude Mythos 5.1 is available to vetted cyberdefenders and life scientists. Currently, it is only available to a set of US organizations, though we’re coordinating with the US government to expand access to a broader set of domestic and international partners as quickly as possible. To register interest in access to Claude Mythos 5.1 for cyberdefense through the CVP, see here https://portal.anthropic.com/programs/cvp . Get started Footnotes 1 These three targets are EGFR, Nipah G, 15-PGDH and come from Adaptyv Bio’s protein design competitions https://proteinbase.com/competitions . The Nipah G comparison is against de novo designs targeting the receptor-binding site on the G head best: ~8–12 nM, N1032 https://proteinbase.com/proteins/shy-otter-jade . A de novo entry from Nick Boyd/Escalante Bio https://blog.escalante.bio/winning-the-de-novo-portion-of-the-adaptyv-nipah-binder-competition/ that targets a different region the stalk reached ~1.4 nM design 7 https://proteinbase.com/proteins/shy-eagle-fern , comparable to our best binder. Further reading 1. The Claude Fable 5.1 and Claude Mythos 5.1. View card https://www.anthropic.com/claude-fable-5-1-mythos-5-1-system-card 2. More detail on our Enterprise Frontier Safeguards. Learn more https://www.anthropic.com/news/enterprise-frontier-safeguards 3. Request access to our Enterprise Frontier Safeguards. Open form https://www.anthropic.com/news/enterprise-frontier-safeguards 4. An overview of our improvements to our biology safeguards. Learn more https://www.anthropic.com/news/improving-fable-5-s-biology-safeguards 5. Support for scientists. Read more https://www.anthropic.com/news/expanding-support-for-scientists 6. Earlier work by Claude in protein design. Read more https://www.anthropic.com/research/Claude-accelerates-protein-design 7. Earlier work by Claude in mathematics. Read more https://www.anthropic.com/research/riemann-zeta 8. More about the Model Hardware Standard. Learn more https://www.anthropic.com/news/model-hardware-standard-research-preview