# Anthropic says Claude drafted routes to four targets from unpublished syntheses

> Source: <https://runtimewire.com/article/claude-synthesis-routes-unpublished-molecules-blind-tests>
> Published: 2026-11-09 22:45:05+00:00

# Anthropic says Claude drafted routes to four targets from unpublished syntheses

**Anthropic says three Claude models each wrote routes to four targets in 26 to 84 minutes. Professors reviewed the plans blind; none has been tested in a lab.**

        By [RuntimeWire Staff](https://runtimewire.com/author/runtimewire-staff)
        · Published 

Primary source: [Claude (official)](https://x.com/claudeai/status/2119899468812386425)

## Why it matters

Route planning consumes expert time before a chemist runs a single reaction, so a model that can draft a credible route from one structure image could change how laboratories allocate graduate-student and postdoc hours. Anthropic's blind design using unpublished targets addresses the recall problem that weakens many chemistry demonstrations.

Anthropic said on November 9th that three Claude models each produced a complete synthetic route to four targets from unpublished syntheses after receiving one image of each target, with no internet, literature or reaction-database access and local code as the only tool. [Claude (@claudeai)](https://x.com/claudeai/status/2119899468812386425?ref=runtimewire) described the work [in a thread on X](https://x.com/claudeai/status/2119899468812386425?ref=runtimewire), and Anthropic published the fuller account in a [report by David…

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