🔬 An Oscar, Two Asteroids, and the Algorithm in Your sklearn: John Platt on AI for Science

Google researcher John Platt and his team developed Empirical Research Assistance (ERA), an AI system that uses Gemini and a Monte Carlo Tree Search-style algorithm to automate scientific discovery by mutating experiment notebooks selected via the Upper Confidence Bound rule. ERA solved enough outstanding problems to produce at least ten papers, including climate change research, with Platt noting a step change in capability between Gemini 2.0 and 2.5 that took the system "from just not working to working great." Platt, who holds an Academy Award, two named asteroids, and an Erdős–Bacon number of 6, described the system as "almost like having a hyper-eager grad student who doesn't sleep.

How often do you get to talk to a guest who has both an Academy Award and who invented textbook machine learning algorithms? John Platt has an Oscar https://www.atogt.com/askoscar/display-person.php?id=78091&var=0 , two textbook https://en.wikipedia.org/wiki/Platt scaling algorithms https://en.wikipedia.org/wiki/Sequential minimal optimization , two named asteroids, and an Erdos-Bacon number https://en.wikipedia.org/wiki/Erd%C5%91s%E2%80%93Bacon number of 6. This was easily the most fun bio of all the guests we’ve read to date. And the result was an epic and fun chat covering Google’s Empirical Research Assistance https://research.google/blog/empirical-research-assistance-era-from-nature-publication-to-catalyzing-computational-discovery/ ERA , how AI can help battle climate change, and tons of great stories about the co-evolution of science and AI. John’s colleague Dave Bacon likes to tease John that his career has been defined by being twenty years early to the next big thing. This may be convolutional neural networks some credit him with coining the term , fusion research, quantum computing. John and Google have been working on solving some of humanity’s hardest problems with AI and computation for well over a decade now. Recently John and his team set their sights on using AI to solve any scientific problem that can be written down as a score. Google’s Empirical Research Assistance ERA John’s team has taken on many hard scientific problems over the years. In solving these, they noticed a pattern, many scientific problems can be reduced to what John calls a “scoreable task”. Once you have the score function, the goal is to find some code that maximizes the score. The hard part is in formulating the score, but once you have the score finding the maximizer can still be quite a lot of effort. John’s team set out to automate solutions to this general problem. This came out of the idea of an “auto-Kaggle” AI, which can solve any Kaggle problem you can throw at it. Kaggle is owned by Google, so all the data was ready and easily available to them The result is Google’s Empirical Research Assistance or ERA paper https://www.nature.com/articles/s41586-026-10658-6 , github https://github.com/google-research/era/tree/main/era applications , blog https://research.google/blog/accelerating-scientific-discovery-with-ai-powered-empirical-software/ . 1 footnote-1 ERA is surprisingly simple conceptually. Gemini or your LLM of choice keeps a running tree of past experiments notebooks and where they’re going. It’s a close cousin of Monte Carlo Tree Search https://en.wikipedia.org/wiki/Monte Carlo tree search : at each iteration the Upper Confidence Bound <https://en.wikipedia.org/wiki/Multi-armed bandit Upper Confidence Bound UCB bandit algorithm rule picks which notebooks are most promising to mutate. This is optimistic, not greedy, so sometimes even the fifth-best notebook gets chosen. Gemini then proposes mutations for each one, about ten at a time. The history of each branch is shared, so different leaves can learn from each other. “It’s almost like having a hyper-eager grad student who doesn’t sleep.” Evolutionary algorithms https://en.wikipedia.org/wiki/Genetic programming have been around since the 70s, but this works because Gemini actually knows where to look What’s even more interesting is that there was a step change between Gemini 2.0 and 2.5, and this went from just not working to working great. ERA is so powerful that John and his team solved many outstanding problems with it, resulting in at least ten papers https://github.com/google-research/era/tree/main/era applications/pdfs . Some of these were climate change related, which we talk about in the next section. So, we had to ask: if you have an optimization god how do you avoid fooling yourself? John’s answer is that ERA provides predictive models. It’s up to the scientist to make sure they’re truly descriptive. Some of this just involves good old-fashioned careful machine learning science. “It’s a power tool. It can slice your fingers off.” This led to some fun discussion about Kaggle competitions, and the fun ways people can overfit to datasets without meaningfully solving the problem you actually care about: Google’s contrail-detection competition was won by entrants who noticed a half-pixel error in the labels is the origin at the corner of the pixel or the center? and this turned out to be a part of the winning special sauce https://www.kaggle.com/competitions/google-research-identify-contrails-reduce-global-warming/writeups/jun-koda-1st-place-solution . Great for winning $15,000, not so helpful if you actually want to solve contrails. “People themselves will act like these LLMs and try to reward hack. It goes back to Goodhart’s law https://en.wikipedia.org/wiki/Goodhart%27s law : any metric that becomes a target is no longer good as a metric.” His advice for where to start instead? “Always just fit linear regression. Just do it. Just do it. Just do it. Or SVM.” Tackling Climate Change with AI John and his team have worked extensively to mitigate the effects of climate change. We talked about several of their initiatives. Perhaps the most interesting result we talked about was reducing the effects of condensation trails contrails from airplanes. Those little streaks you see running behind planes somehow account for 1% of all human-induced global warming https://doi.org/10.1016/j.atmosenv.2020.117834 ? ? Some of these trails of ice crystals can hang out for days. These crystals are black in the infrared, acting like a thermal blanket that traps heat day and night. It’s easy to understand what’s happening here, a region of atmosphere becomes “ice supersaturated”, 2 footnote-2 and a tiny bit of exhaust seeds water vapor that instantly crystallizes. The scale here is astounding, with a single gram of exhaust resulting in ten kilograms of ice crystals. The solution to all of this is quite simple, in principle We know what parts of the atmosphere are most likely for the trails to form. Just have the planes drop a flight level or two. Problem solved, right? Well, the hard part is accounting for how much warming was prevented. This is a counterfactual problem, parts of which stumped John’s team for over two years. They had a working model for the heat-trapping half https://doi.org/10.5194/amt-19-1951-2026 , but not for the reflected sunlight. ERA was able to find a simple model with some confounders they hadn’t considered. Cracked it Modeling climate generally is a hard problem. Climate is best thought of an attractor of many different possible weather outcomes. 3 footnote-3 This makes it much harder to model. “Weather is where you are on the attractor https://en.wikipedia.org/wiki/Lorenz system , and climate is the statistics of the attractor. The problem with climate is that we’re altering it. The attractor itself is changing, it’s moving.” John and his team have worked on treating both the symptoms and the disease of climate change, with several other works in the area. Another fun example we briefly cover is FireSat, a way of using a constellation of satellites to rapidly identify fires before they grow too big to put out. For anyone living in California, you understand the problem. In dry years a small fire can result in hundreds of thousands of acres. If you could find this fire when it’s the size of a room, it could be put out. By the time it hits an acre we have a much harder problem. Where is this all going? Looking forward by looking back By now it should be clear John has an incredible and unique view over the intersection of science, computation, and AI. John talked about a class on physics of computation https://en.wikipedia.org/wiki/Feynman Lectures on Computation 4 footnote-4 he took with Richard Feynman back in 1982. This was when quantum computing was an ill-defined concept with no theory or experimental backing. John recalls every Tuesday was a guest lecture, and every Thursday was Feynman explaining why the Tuesday guest was wrong. John also recalls doing science back when there was essentially no compute, a million operations per second was cutting edge. What is John’s recommendation: the most important skill is developing deep domain expertise. There’s no other way to develop taste than to tackle hard problems. One surprising part of this is that John recommends spending time doing things the old fashioned way. Play with tools, and just implement things yourself. “You could drive up the mountain, or you could hike up the mountain, and maybe it’s okay, even fun, to occasionally hike.” Summing it up, John’s message to the audience is that there will still be a place for scientists, and that if anything it will just open up more opportunities for “the creative stuff, the rigorous stuff, the philosophy stuff.” But don’t forget to spend time doing the grunt work. “There just seems to be this strong impetus in the world to optimize and squeeze everything out. But you do lose something when you hyper-optimize. It’s overfit.” And whatever tools you end up using, John’s advice is the same one Feynman gave him https://calteches.library.caltech.edu/51/2/CargoCult.htm forty years ago: you must not fool yourself, and you are the easiest person to fool. We had a great time talking with John. We hope you enjoy Also in this episode - Fusion is three years away, not thirty, if you ask John. And why the Lawson criterion https://en.wikipedia.org/wiki/Lawson criterion means every fusion approach has an Achilles heel. - Why superconducting qubits are still finicky. - The asteroid he named after his mom, which turned out to have a moon. - The looming helium shortage https://en.wikipedia.org/wiki/Federal Helium Reserve nobody talks about. - How NeurIPS started as people crashing a private workshop at Snowbird, and why Hopfield networks are all you need https://arxiv.org/abs/2008.02217 . - Being Carver Mead’s sysadmin on a VAX with an 80 MB disk the size of a dishwasher. - Finding asteroids in 1985 with film, a stereoscope, and a letter to Brian Marsden. The Vera Rubin Observatory https://en.wikipedia.org/wiki/Vera C. Rubin Observatory found 11,000 in six weeks. - The Feynman effect: total clarity in the room, none once you leave. - Quantum echoes, the NISQ era https://en.wikipedia.org/wiki/Noisy intermediate-scale quantum era , and why he thinks quantum is neither thirty years away nor tomorrow. - A startup that wants to inject mercury into a fusion reactor and sell the transmuted gold. “It might not work.” - John’s 20% time rule for his own group: do stuff for learning, and you don’t even have to tell him what. 1 footnote-anchor-1 The ERA GitHub repo https://github.com/google-research/era/tree/main/era applications features an open source implementation that ran Gemini but can be used with any LLM. ERA is not currently available as a Google product. 2 footnote-anchor-2 “Ice-supersaturated” is about water vapor, not liquid water. Cold air can hold a given amount of vapor, and there are two different limits: the amount in equilibrium with liquid water, and the smaller amount in equilibrium with ice. Below freezing, a pocket of air can sit between those two limits. It has more vapor than ice can tolerate, but not enough to condense into droplets, and ice won’t form directly from vapor without a seed. So the vapor just hangs there, metastable, sometimes for days, until something seeds it. 3 footnote-anchor-3 We recently covered the weather-climate crossover in our episode with Anima Anandkumar https://www.latent.space/p/anima , and we plan on covering both weather and climate more in future episodes. 4 footnote-anchor-4 This was really about quantum computing, but in the early days before anyone really knew what this meant and it was just a vague idea Feynman and a few others were kicking around.