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An Introduction to Bayesian and Frequentist Simulation-Based Inference with Machine Learning

A new paper on arXiv (submitted July 23, 2026) provides an overview of Bayesian and frequentist simulation-based inference (SBI) with machine learning, covering methods such as neural posterior estimation and neural likelihood estimation for parameter estimation, Empirical Bayes, and unfolding tasks. The authors also discuss validation of inference results and limitations of SBI with machine learning.

read1 min views1 publishedJul 27, 2026
An Introduction to Bayesian and Frequentist Simulation-Based Inference with Machine Learning
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[Submitted on 23 Jul 2026]


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Abstract:Simulation-based inference (SBI) with machine learning is an increasingly important tool for solving inverse problems in science and engineering, including parameter inference and the inversion of detector effects. We provide an overview of the Bayesian and frequentist statistical frameworks, describe how machine-learning-based SBI methods, such as neural posterior estimation and neural likelihood estimation, can be used for parameter estimation within these frameworks, and show that the same methods can also be applied to Empirical Bayes or unfolding tasks. We also discuss how to validate inference results and the limitations of SBI with machine learning.

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