# AI solves 18 medical mysteries in ‘total game changer’ for patients > Source: > Published: 2026-06-20 14:28:58+00:00 # AI solves 18 medical mysteries in ‘total game changer’ for patients - A new study published in *NEJM AI*indicates that OpenAI’s o3 model can help diagnose previously unsolved medical mysteries. - The AI model, released in April 2025, assisted in identifying new diagnoses for 18 children at Boston Children’s Hospital, including those with rare neurodevelopmental and neuromuscular disorders. - Researchers analysed 376 genomes from undiagnosed patients, with the AI model successfully identifying nearly five per cent of new diagnoses, a result described as a “total game changer.” - One patient, Kyra Benton, who had experienced undiagnosed symptoms since age nine, finally received a diagnosis of myofibrillar myopathy with the aid of the AI. - The study highlights that the AI model functions as a diagnostic tool, processing patient data and doctors' notes, with human review essential for final diagnoses, and is not intended for self-diagnosis.